Harmonized Interpretable ECG Waveform Features for Robust Cross-Dataset Clinical Prediction

Jie Lin, Weijie Sun, Sunil V Kalmady, Anita Khalafbeigi, Abram Hindle, Padma Kaul, Russell Greiner

2026/04/20

Harmonized Interpretable ECG Waveform Features for Robust Cross-Dataset Clinical Prediction

Authors

Jie Lin, Weijie Sun, Sunil V Kalmady, Anita Khalafbeigi, Abram Hindle, Padma Kaul, Russell Greiner

Venue

Abstract

Electrocardiograms (ECGs) are widely used for cardiovascular risk prediction, yet models often fail to transfer across hospitals because of protocol, population, and measurement differences. We benchmark cross-dataset generalization on three tasks - heart failure classification, 30-day all-cause mortality, and 30-day mortality among sinus-rhythm ECGs - using two large cohorts (MIMIC-IV and the Alberta Cohort). To reduce vendor-specific measurement mismatch, we build a harmonized, interpretable feature representation computed directly from raw waveforms: FeatureDB morphology/heart-rate-variability summaries plus compact time-frequency descriptors (autoregressive and wavelet features). We train XGBoost models on this unified feature space and evaluate with patient-disjoint internal and bidirectional external testing. We pre-specify

Bibtex

@inproceedings{jielin2026-harmonized,
 abstract = {Electrocardiograms (ECGs) are widely used for cardiovascular risk prediction, yet models often fail to transfer across hospitals because of protocol, population, and measurement differences. We benchmark cross-dataset generalization on three tasks - heart failure classification, 30-day all-cause mortality, and 30-day mortality among sinus-rhythm ECGs - using two large cohorts (MIMIC-IV and the Alberta Cohort). To reduce vendor-specific measurement mismatch, we build a harmonized, interpretable feature representation computed directly from raw waveforms: FeatureDB morphology/heart-rate-variability summaries plus compact time-frequency descriptors (autoregressive and wavelet features). We train XGBoost models on this unified feature space and evaluate with patient-disjoint internal and bidirectional external testing. We pre-specify},
 accepted = {2026-04-20},
 author = {Jie Lin and Weijie Sun and Sunil V Kalmady and Anita Khalafbeigi and Abram Hindle and Padma Kaul and Russell Greiner},
 authors = {Jie Lin, Weijie Sun, Sunil V Kalmady, Anita Khalafbeigi, Abram Hindle, Padma Kaul, Russell Greiner},
 booktitle = {39th IEEE International Symposium on Computer-Based Medical Systems (CBMS)},
 code = {jielin2026-harmonized},
 date = {2026-06-03},
 doi = {https://doi.org/10.48550/arXiv.2607.23412},
 funding = {NSERC Discovery},
 location = {Limassol, Cyprus},
 pagerange = {1--2},
 pages = {1--2},
 role = {Co-Author},
 title = {Harmonized Interpretable ECG Waveform Features for Robust Cross-Dataset Clinical Prediction},
 type = {inproceedings},
 url = {http://softwareprocess.ca/pubs/jielin2026-harmonized.pdf},
 venue = {39th IEEE International Symposium on Computer-Based Medical Systems (CBMS)},
 year = {2026}
}