Harmonized Interpretable ECG Waveform Features for Robust Cross-Dataset Clinical Prediction
Authors
Jie Lin, Weijie Sun, Sunil V Kalmady, Anita Khalafbeigi, Abram Hindle, Padma Kaul, Russell Greiner
Venue
- 39th IEEE International Symposium on Computer-Based Medical Systems (CBMS)
- Limassol, Cyprus
- 2026
- 1–2
- DOI:https://doi.org/10.48550/arXiv.2607.23412
Abstract
Electrocardiograms (ECGs) are widely used for cardiovascular risk prediction, yet models often fail to transfer across hospitals because of protocol, population, and measurement differences. We benchmark cross-dataset generalization on three tasks - heart failure classification, 30-day all-cause mortality, and 30-day mortality among sinus-rhythm ECGs - using two large cohorts (MIMIC-IV and the Alberta Cohort). To reduce vendor-specific measurement mismatch, we build a harmonized, interpretable feature representation computed directly from raw waveforms: FeatureDB morphology/heart-rate-variability summaries plus compact time-frequency descriptors (autoregressive and wavelet features). We train XGBoost models on this unified feature space and evaluate with patient-disjoint internal and bidirectional external testing. We pre-specify
Bibtex
@inproceedings{jielin2026-harmonized,
abstract = {Electrocardiograms (ECGs) are widely used for cardiovascular risk prediction, yet models often fail to transfer across hospitals because of protocol, population, and measurement differences. We benchmark cross-dataset generalization on three tasks - heart failure classification, 30-day all-cause mortality, and 30-day mortality among sinus-rhythm ECGs - using two large cohorts (MIMIC-IV and the Alberta Cohort). To reduce vendor-specific measurement mismatch, we build a harmonized, interpretable feature representation computed directly from raw waveforms: FeatureDB morphology/heart-rate-variability summaries plus compact time-frequency descriptors (autoregressive and wavelet features). We train XGBoost models on this unified feature space and evaluate with patient-disjoint internal and bidirectional external testing. We pre-specify},
accepted = {2026-04-20},
author = {Jie Lin and Weijie Sun and Sunil V Kalmady and Anita Khalafbeigi and Abram Hindle and Padma Kaul and Russell Greiner},
authors = {Jie Lin, Weijie Sun, Sunil V Kalmady, Anita Khalafbeigi, Abram Hindle, Padma Kaul, Russell Greiner},
booktitle = {39th IEEE International Symposium on Computer-Based Medical Systems (CBMS)},
code = {jielin2026-harmonized},
date = {2026-06-03},
doi = {https://doi.org/10.48550/arXiv.2607.23412},
funding = {NSERC Discovery},
location = {Limassol, Cyprus},
pagerange = {1--2},
pages = {1--2},
role = {Co-Author},
title = {Harmonized Interpretable ECG Waveform Features for Robust Cross-Dataset Clinical Prediction},
type = {inproceedings},
url = {http://softwareprocess.ca/pubs/jielin2026-harmonized.pdf},
venue = {39th IEEE International Symposium on Computer-Based Medical Systems (CBMS)},
year = {2026}
}